Subject attrition from randomized Schizophrenia trials is a significant problem and has been found in meta-analysis to be as high as 76% (Robinowitz et al., 2005). High drop-out rates introduce selection bias, decrease the validity of intent to treat (ITT) analysis, can lead to a decrease in statistical power, and can ultimately cloud signal detection. The problem of drop-out is typically not addressed until the statistical analysis stage of the study which can decrease the validity of the results, increasing the likelihood of failed and negative trials.
Salt Lake City Research Unit
Video highlighting Salt Lake City Resarch Unit, and its capabilities
Select Characteristics of Recreational Opioid Users Undergoing a Human Abuse Potential Study
Human abuse potential (HAP) studies are conducted to determine the potential abuse of a drug that has rewarding properties. Abuse potential refers to…
PRA’s Vaccine Solutions group understands the unique challenges and characteristics of vaccine development. Right from the start, our experts will…