Subject attrition from randomized Schizophrenia trials is a significant problem and has been found in meta-analysis to be as high as 76% (Robinowitz et al., 2005). High drop-out rates introduce selection bias, decrease the validity of intent to treat (ITT) analysis, can lead to a decrease in statistical power, and can ultimately cloud signal detection. The problem of drop-out is typically not addressed until the statistical analysis stage of the study which can decrease the validity of the results, increasing the likelihood of failed and negative trials.
A Blueprint to Success: Onboarding a Medical Writer
Onboarding is the process of welcoming new employees into an organization and providing them with the tools, resources, and knowledge to become…
Join PRA in China
The expertise of a global CRO + local know-how to deliver the highest caliber of clinical development services around the world.
ECG Assessments During the Development of Oncology Compounds
Single-center oncology studies performed by dedicated PRA staff, combined with the High Precision QT approach of iCardiac, generates conclusive ECG…