Subject attrition from randomized Schizophrenia trials is a significant problem and has been found in meta-analysis to be as high as 76% (Robinowitz et al., 2005). High drop-out rates introduce selection bias, decrease the validity of intent to treat (ITT) analysis, can lead to a decrease in statistical power, and can ultimately cloud signal detection. The problem of drop-out is typically not addressed until the statistical analysis stage of the study which can decrease the validity of the results, increasing the likelihood of failed and negative trials.
Global Capabilities in Central Nervous System
PRA Health Sciences’ Early Development Services (EDS) group has a long-standing record of early clinical development work in various neuroscience and…
Salt Lake City Research Unit
Video highlighting Salt Lake City Resarch Unit, and its capabilities
Human Abuse Liability Studies: Not Your Traditional Phase I Study
Abuse potential refers to the likelihood for a drug to be used in nonmedical situations for its positive psychoactive effects. PRA Health Sciences’…