Putting patients first and simplifying their experiences with well-chosen decentralized techniques promises to improve clinical trials for everyone.

This article explores the design of a protocol that includes decentralized components. After a clinical-trial protocol has been developed, adding decentralized components—such as wearable devices for data collection or telemedicine visits—gets complicated. It is significantly easier to incorporate decentralized elements while designing the protocol, similar to how wiring a house during construction is easier than wiring post-construction.

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