It’s the final full week of April and this week we bring you news stories covering better understanding COVID-19, specifically the differences in immune responses which may be key to finding treatments, and news of a team of researchers engineering specific virus-targeting receptors onto a patient's own immune cells as a potential therapy for controlling infectious diseases, including SARS-CoV-2. As well as this we bring you news of research that may help make immunotherapy treatments more effective for cancer patients, CRISPR edited stem cells in diabetes, anti-TNF therapy for psoriasis, and a new advisory board to help primary care providers better serve migraine patients.
Could Curbing Runaway Immune Responses Treat COVID-19?
Among the many outstanding questions about COVID-19 is how the same virus, SARS-CoV-2, can be fatal to some patients and leave others unaware they were ever exposed. Clinical evidence combined with hints from laboratory research indicate that for at least some patients with severe cases, the primary danger comes from a runaway immune response that irreparably injures tissue, researchers say. Understanding the mechanisms behind that response could be key to finding a treatment for those patients.
Scientists Explore Using 'Own' Immune Cells to Target Infectious Diseases Including COVID-19
The engineering of specific virus-targeting receptors onto a patient's own immune cells is now being explored by scientists as a potential therapy for controlling infectious diseases, including the COVID-19-causing virus, SARS-CoV-2.
New Findings Could Make Immunotherapy Treatments Effective for More Cancer Patients
Scientists have developed a new way to map the molecules on tumor cells that flag their presence to the immune system, the findings could make commonly used immunotherapy treatments effective for a much larger population of cancer patients.
Diabetes Reversed in Mice With CRISPR-Edited Stem Cells from Patients
Researchers at Washington University School of Medicine in St. Louis have transformed stem cells into insulin-producing cells. They used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes and implanted the cells into mice to reverse diabetes in the animals.
American Headache Society collaborates with PCPs to improve migraine care
A new advisory board commissioned by the American Headache Society is developing strategies to improve migraine care in primary care offices. The board represents physicians in internal medicine, family medicine, obstetrics and gynecology, neurology and headache medicine. They are collaborating to better equip front-line primary care providers with the education and support needed to more effectively diagnose and treat headache disorders.
Anti-TNF Therapy Efficacy Differs by Gender
A study showing differences in baseline characteristics between responders to anti-tumor necrosis factor (anti-TNF) therapy and insufficient responders may be helpful to dermatologists as they consider treatment for patients with moderate-to-severe psoriasis, according to researchers.