As we move into week 7 of 2020, we bring you a selection of news stories based around neurological research. As cell and gene therapies advance, we will begin to see broader application across therapeutic areas, in neuroscience this may include indications such as Parkinson’s and ALS. Technological advances continue to support this area of research, a large study in the UK is beginning, in which 1 million people are tracking early signs of Alzheimer’s using a smartwatch. A long-term study has also indicated that cognitive decline in MS may not be inevitable, as previously thought. In regulatory news, the FDA has recently issued a guidance for the rare disease, Sanfilippo Syndrome – for which there is no current treatment.
Cognitive Decline in MS May Not Be Inevitable or Progressive, 10-year Study Suggests
Statistics indicate that some kind of cognitive impairment affects up to two-thirds of all MS patients, including memory deficits or problems with processing information. Once a patient starts showing signs of cognitive decline, it is often assumed symptoms will inevitably worsen as MS progresses. However, findings from a new study carried out by researchers in Greece are challenging this scenario.
Gene ID'd as Potential Therapeutic Target for Dementia in Parkinson's
Researchers have discovered that the genetic variant APOE4 -- long linked to dementia -- spurs the spread of harmful clumps of Parkinson's proteins through the brain. The findings suggest that therapies that target APOE might reduce the risk of dementia for people with Parkinson's disease.
Alzheimer's Research UK Launches Global Use of Smartwatches to Detect Early Signs of Dementia
One million people in the UK are trialing wearing a smartwatch style device to detect early signs of dementia by using artificial intelligence to monitor more than 30 indicators, such as speech, gait, fine motor skills and sleep.
New Spinal Delivery Method Renders Stem Cell Therapy Safer for ALS
A new spinal cell delivery method may reduce the risks and boost the effectiveness of stem cell therapy designed to regenerate the nervous system in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), an early study in rats has found.
Google Recently Created the Most Detailed Image of a Brain Yet
Scientists have created the most detailed 3D map of an organism brain to date. The mesmerizing threads of blue, yellow, purple and green represent thousands of brain cells and millions of connections found inside the brain of a fruit fly.
FDA Releases Guidance for Rare Disease Known as Sanfilippo Syndrome
The US FDA has issued a draft guidance for a rare condition known as Sanfilippo Syndrome, said guidance provides recommendations to industry on important clinical trial design features that can support a robust clinical development program for the development of therapies to treat this rare and life-threatening disorder.